Association of Raised Gamma Glutamyl Transferase (GGT) Levels in Patients with Acute Coronary Syndrome and Their in Hospital Outcome

Objective: To determine the frequency of raised serum GGT levels in patients with acute coronary syndrome and their in-hospital outcome. Study design: Case descriptive. Subjects and methods: 120 patients hospitalized in CCU of Services Hospital, Lahore with the diagnosis of Acute Coronary Syndrome (ACS) were included in study. All had baseline serum GGT level determined and outcome in terms of Major Adverse Cardiac Event (MACE), which included mortality from cardiac cause and recurrent MI, was studied within 4 days of hospital stay. Results: Among all participants 36 (30.0%) patients had raised GGT (>40U/L). In STEMI 35.4% NSTEMI 19.4% and unstable angina 20.0% had raised GGT levels. In CCU 23 (19.2%) patients suffered MACE (7 died). 60.9% of patients with MACE had raised GGT levels. Conclusion: Raised serum GGT activity was found to be a strong predictor of the development of MACE in the patients with ACS during CCU. And significant association of GGT with diabetes mellitus and obesity may account, at least in part, for the prognostic role of GGT.